Diuretics - potassium-sparing diuretics

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Medications

Potassium-sparing diuretics include:

  • Amiloride (Midamor)
  • Spironolactone (Aldactone)
  • Triamterene (Dyrenium)

Potassium-sparing diuretics and thiazide diuretics may sometimes be used together. Diuretic combinations include:

  • Hydrocholorothiazide/triamterene (Maxzide, Dyazide)
  • Hydrochlorothiazide/ spironolactone (Aldactazide)
  • Amiloride/ hydrochlorothiazide (Moduretic)

Depletions from potassium-sparing diuretics are discussed in this article. If you are taking any of these combinations, you may also want to consult the thiazide diuretics depletion article.

Depletions

Taking triamterene may deplete vitamin B9.

Vitamin B9 (Folic Acid)

Low levels of folic acid in the body may be linked to:

  • Anemia
  • Heart disease
  • Birth defects

Symptoms may include:

  • Weakness
  • Mouth sores
  • Swollen tongue
  • Depression
  • Poor growth

Editorial Note

The information presented here covers some of the nutrients that may be affected when you take certain medicines. If you have any of these signs and symptoms, it does not always mean you have low levels of these nutrients.

Factors that affect the level of nutrients are:

  • Your medical history
  • Diet
  • Lifestyle
  • How long you have been taking the medicine

Please talk to your health care provider. They can best address your health care needs and see if you are at risk for low levels of any nutrients.

Supporting Research

Gold Standard Drug Database. Drug Monograph: Triamterene, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-626. Accessed July 5, 2016.

Gold Standard Drug Database. Drug Monograph: Hydrochlorothiazide, HCTZ; Spironolactone, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1085. Accessed July 19, 2016.

Gold Standard Drug Database. Drug Monograph: Hydrochlorothiazide, HCTZ; Triamterene, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1087. Accessed July 19, 2016.

Gold Standard Drug Database. Drug Monograph: Amiloride; Hydrochlorothiazide, HCTZ, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-863. Accessed July 19, 2016.

Hoorn EJ, Wilcox CS, Ellison DH. Diuretics. In: Skorecki K, Chertow GM, Marsden PA, Yu ASL, Taal MW, eds. Brenner and Rector's The Kidney. 10th ed. Philadelphia, PA: Elsevier; 2016:chap 51.

Sachdev HPS, Shah D. Vitamin B complex deficiencies and excess. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 49.

Shenkin A, Roberts NB. Vitamins and trace elements. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed. St. Louis, MO: Elsevier Saunders; 2012:chap 31.

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